This amino acid inhibits the formation of advanced glycation end products (AGEs), a common consequence of high heat extruded kibble-based diets. Carnosine may also play an important role in both slowing the onset of and potentially reversing the effects of cognitive dysfunction in dogs.

Berberine turns on AMP-activated protein kinase, an important longevity pathway, while promoting healthy cellular autophagy (the removal of dysfunctional or damaged cells). It also supports healthy glucose management while protecting against some of the harmful effects of high blood sugar.

For centuries, this ancient herb has been prized for its longevity-conferring benefits. Through modern research it's now understood to activate AMPK, which in turn increases ATP production and decreases energy consumption by responding to cellular stress.

Quercetin has been shown to directly increase the expression of longevity genes such as SIRT-1 in human aging skin fibroblasts and other animal models. It's also one of the best-studied senloytics, a class of molecules that helps the body remove senescent (old and dysfunctional) cells. Quercetin's anti-inflammatory, antioxidant, and antihistamine properties have also earned it the nickname "Nature's Benedryl", and it may provide occasional relief of seasonal allergies.

Resveratrol helps activate the SIRT-1 gene, prized for its broad longevity benefits. It's also a powerful antioxidant that supports and protects the brain and heart.

Pterostilbene is a natural dietary compound and the primary antioxidant component of blueberries. It's known for its longevity-supporting ability to activate the Sirtuin pathway while providing antioxidant support for the brain and heart.

PQQ is a unique antioxidant that protects vulnerable mitochondria (the powerhouse of the cells), particularly in the heart and brain. It also supports mitochondrial biogenesis—the formation of new mitochondria within cells.

Discovered by a group of MIT scientists, including a Nobel Prize laureate, Magtein® stands apart from other magnesium forms. It traverses the blood-brain barrier to elevates magnesium levels in the brain and cerebrospinal fluid. This leads to enhanced learning abilities, improved working memory, and better short-and-long-term memory in animals.

Lion's Mane Mushroom enhances brain function and memory. It bypasses the blood-brain barrier to stimulate the production of NGF (nerve growth factor) and Brain-Derived Neurotrophic Factor. Additionally, Lion's Mane provides cardiovascular, immune, and prebiotic support.

Abundant in the antioxidant polyphenol anthocyanin, Blueberry Extract diligently safeguards your dog's brain cells.

L-Theanine is an amino acid primarily found in green tea, black tea, and mushrooms. It fosters a serene mood, promotes relaxation, and encourages restful sleep.

Ginko Biloba stimulates blood flow to the brain and extremities, promoting cognitive function and memory.

Pyridoxal-5-Phosphate is the biologically active form of Vitamin B6, playing a pivotal role in the production of various neurotransmitters, including dopamine, serotonin, and GABA. Dopamine is associated with the brain's reward system, serotonin promotes positive emotions, and GABA regulates nervous system excitability.

This methylated form of Vitamin B-12 supports the healthy functioning of the brain and nervous system.

Crafted through slow dehydration to concentrate its beneficial components, traditional bone broth is a potent supporter of strong joints and connective tissue. It goes above and beyond, aiding in the maintenance of a healthy liver, immune system, and gut function.

Collagen, a critical component in maintaining cartilage strength, also plays a pivotal role in promoting proper inflammatory responses associated with occasional joint discomfort. Beyond joint support, collagen facilitates muscle recovery post-activity and helps shield against specific tendon and ligament injuries. Additionally, it contributes to healthy digestion and promotes coat health.

This remarkable functional mushroom stands as a stalwart ally in the realm of joint health and comfort. It reduces inflammation and bolsters immune function. Reishi also boasts adaptogenic properties that combat fatigue and promote post-exercise recovery.

Shiitake Mushrooms play a significant role in promoting joint health and comfort through its anti-inflammatory properties. It actively reduces inflammation, which is essential for maintaining optimal joint function and alleviating discomfort. It's also a natural source of B Vitamins and Vitamin D, providing additional health benefits that contribute to overall well-being.

Chondroitin Sulfate assumes a crucial role in preserving your dog's natural joint lubrication and serves as a foundational building block for cartilage.

Glucosamine steps in to support the healthy production of cartilage cells and synovial fluid, facilitating increased lubrication between joints.

This natural form of sulfur is a versatile asset, preserving cartilage and reducing joint discomfort. Its benefits extend to numerous other health advantages for the whole body.

Renowned for its anti-inflammatory properties, Turmeric proves invaluable in nurturing joint health and comfort. It's also a natural source of B Vitamins and Vitamin D, providing additional health benefits.

Tart cherries are a naturally high source of anthocyanins that reduces free radical formation and inflammation.

Helps increase hyaluronic acid within joints, lubricating joints and providing important shock reduction.

Ginger root reduces gas and bloating, and helps settle sensitive stomachs. Ginger also supports a healthy inflammatory response to provide additional full-body benefits.

Pumpkin seed supports gut health and may provide natural protection from a variety of intestinal parasites. It also helps reduce inflammation of the anal gland, which can relieve irritation.

This natural amino acid increases the expression of tight junction proteins and the integrity of the intestinal lining. L-Glutamine also supports healthy gut bacteria levels and reduces inflammation.

Supports healthy gut and intestinal lining, reduces inflammation, and helps support a healthy balance of beneficial gut bacteria.

Rich in beta glucans and beneficial terpenes, Turkey Tail mushroom is a functional powerhouse that boosts immune function and helps defend against malignant cell growth.

Sulforaphane supports cellular detoxification by stimulating Nrf2 which causes the production of certain Phase II metabolic enzymes—a battery of critical proteins that detoxify xenobiotics by increasing their hydrophilicity and enhancing their disposal. Nrf2 upregulates protective enzymes and proteins to help protect cells from oxidative stress.

DIM supports beneficial estrogen metabolism, particularly in neutered/spayed dogs with impaired sex hormone production.

This bioavailable form of zinc supports healthy immune function and hormone production.

Long used in traditional Chinese medicine to support healthy kidney, adrenal, lung, liver, and digestive function. Schisandra also reduces inflammation and helps the body cope with stress and fatigue.

This prized adaptogenic herb is a staple of traditional ayurvedic medicine and has been extensively studied in the West for its beneficial stress-modulating effects, including its ability to reduce the production of the stress hormone cortisol.

Taurine regulates blood flow throughout your dog's body, which helps to strengthen the heart's walls. This important amino acid is also deficient in many grain-free diets, making supplementation a prudent precautionary measure. Research in animal models also suggests that Taurine supplementation may promote longevity and healthy aging.

Milk thistle provides powerful support and protection for the liver. It also reduces histamine production, and supports healthy pancreatic function.

CoQ10 is an antioxidant that supports healthy heart and neurological function. Among other mechanisms, it supports the health of mitochondria (the powerhouse of cells) in heart and brain tissue.

This highly active, bioavailable form of Vitamin K confers exceptional cardiovascular benefits, notably by helping reduce and reverse the buildup of harmful plaque in the arterial walls.

NAC reduces tissue damage caused by oxidative stress and is especially protective of the liver. It’s also a precursor to glutathione—the body's "master antioxidant" that is critical to dozens of anti-inflammatory and detoxification processes.

Green tea extract is an extensively tested antioxidant that provides protective support for the brain and heart while supporting a healthy immune response and reducing inflammation.

Also known as Thiotic Acid, ALA is a powerful antioxidant in its own right, but also acts as an electron donor to effectively recycle and extend the antioxidant capacity of other beneficial supplements like Vitamin C and CoQ10.